|Dr. Dvir's Research: Molecular Mechanisms of Gene Transcription|
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Protein Phosphorylation in the Transcription Complex:
A Primary Mechanism for Regulation
Protein phosphorylation has long been recognized as one of the major mechanisms by which organisms control enzymatic activities in the cell. Several proteins in the transcription complex become phosphorylated during early transcription. One of the most studied is RNA Polymerase II. The largest subunit of the polymerase becomes extensively phosphorylated during the early steps of transcription. The role of this phosphorylation has not been determined as of yet. Also, it is not known exactly when during early transcription the phosphorylation reaction takes place. One of the current goals of Dr. Dvir’s research is to characterize the phosphorylation reaction and gain insights into its physiological function.
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